By: Mai M. El-Keiy¹, Menna Allah M. youssef ², Azza A. Bakry² and

Tarek M. Mohamed¹

1 Biochemistry Department, Faculty of Science, Tanta University,Egypt

2 Food Technology Research Institute, Agricultural Research Centre, Giza, Egypt.

Abstract

Alzheimer’s disease (AD) is the most common age-related dementia characterized by cognitive decline and devastating neurodegeneration.The aim of present work was to evaluate the role of bioactive component boswellic acid in improvement cholinergic deficiency in experimental rat model.In this study rats were divided into five groups as group 1 (control group), group 2 (boswellic acid group), group 3 (AD group), group 4 (boswellic acid –pre-treated group) and group 5 (boswellic acid treated group). At the end of experiment totally different neurochemicals, biochemical analysis was assessed. In AD group (G3) acetylcholine was decreased with acetyl cholinesterase elevation as compared to the control groups (G1 and G2). Improvement of acetyl cholinesterase activity and acetyl choline level was observed after pre and treated (G4 and G5) by boswellic acid. There was a significant decrease in the dopamine in hippocampus of AD group (G3)as compared to the control groups (G1 and G2).In contrast pretreated and treated groups by boswellic acid (G4 and G5, respectively) led to elevation of dopamine concentration, with best improvement in pre-treated group(G4)than treated group (G5). In conclusion; the bowsellic acid improved the cholinergic deficiency in Alzheimer disease.

Effect of boswellic acid in Alzheimer’s disease in experimental rat-converted (1)

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