Vol.8 No.3 – 10:Effect of calcium hypochlorite as a source of hypochlorous acid in ameliorating cyclophosphamide-induced pulmonary and cardiac injury in mice

By: Maher M. Akl^a, Entsar A. Nazmy^b, Omar A. El-Khouly^c*

a Faculty of Science, Mansoura University, 35516, Mansoura, Egypt.

b Critical Care and Emergency Department, Kafr ElSheikh Directorate of Health, Ministry of Health and Population, Egypt

c Faculty of Pharmacy, New Mansoura University, New Mansoura, Egypt

Abstract:

Acute respiratory distress syndrome (ARDS) is recognized to be accompanied by severe lung and heart complications. This study aimed to demonstrate the efficacy of Calcium hypochlorite in cyclophosphamide (CP)-induced pulmonary and cardiac injury in mice. The CP-induced toxicity in the lung and heart is like that caused by ARDS. Calcium hypochlorite significantly attenuated doth lung and heart functionality and significantly reduced the CP-induced perivascular inflammation, congestion of blood vessels, and severe morphological changes of the alveolar wall. It also exerts anti-inflammatory and antioxidant effects on CP-induced pulmonary and heart toxicity. Given these results, calcium hypochlorite successfully ameliorates ARDS symptoms rendering calcium hypochlorite to be a promising agent to be tested in models of pneumonia caused by bacterial or viral infections, including those of acute respiratory distress syndrome (ARDS).

Effect-of-calcium-hypochlorite-as-a-source-of-hypochlorous-acid-in-ameliorating-cyclophosphamide-induced-pulmonary-and-cardiac-injury-in-mice-1

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