Vol.5 No.1 – 7 : The utility of biomarkers in the discrimination of acute coronary syndrome patients

By : Mohamed M. Omran^a*, Faten M. Zahran^b, Mohamed Kadry^c,

Arafa A. M. Belal ^c, Hesham S. Abd Alsamie^d 

^a Chemistry Department, Faculty of Science,  Helwan University, Cairo, Egypt;

^b Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt;

^c Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt;

^d Clinical Pathology Department, Faculty of Medicine, New Damietta, Al-Azhar University, Egypt;

Abstract

Background: The assessment of acute coronary syndrome (ACS) provides useful data not only for identification but also for therapeutic decisions. Objective: To develop a score based on cardiac biomarker for the early diagnosis of ACS patients. Methods: Serum concentrations of myeloperoxidase (MPO) and monocyte chemoattractant protein-1 (MCP-1) beside cardiac troponin I (cTnI) and creatine kinase MB (CK-MB) were measured in a total 200 chest pain patients represented in two groups (estimation and validation). The diagnostics value of biomarkers for discriminating ACS patients was evaluated by area under receiver-operating characteristic curve (AUC). Multivariate discriminant analysis (MDA) was used to create a predictive score. Results: A novel score depends on combination of cTnI, CK-MB, MPO and MCP-1 produces AUCs of 0.93 for discriminating ACS patients and 0.90 for acute myocardial infarction (AMI). This score correctly classified 95% of ACS patients and 93% of AMI patients with good efficiencies were 88.3% and 81%; respectively. This score had similar results in the validation study. Conclusion: Four biomarkers in combination yield a novel score help in the early and safe prediction of ACS and AMI.

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