Vol.2 No.12 -1 : The influence of naringenin on lambda-cyhalothrin induced nephrotoxicity in male rats.

By : Ahmed Mokhtar Abu El-Saad

Abstract

This study aims to evaluate the protective role of naringenin (NGN) against biochemical changes induced by lambda-cyhalothrin (LCT) in the kidney of male rats. The animals were randomized into four groups (n=7/group). Group 1 was the control group. Group 2 received LCT (6.12 mg/kg bw, via gavage) once per day. Group 3 received NGN (50 mg/kg bw, via gavage), 30 min following LCT (6.12 mg/kg bw, via gavage). Group 4 received NGN (50 mg/kg bw, via gavage) for 21 days. By the end of the experimental period, exposure of rats to LCT, the following indices significantly increased compared with the control: serum levels of creatinine and urea; level of malondialdehyde (MDA), Nitric oxide (NO), interleukin-8 (IL-8) and activities of Nitric oxide synthetase (NOS), Cytochrome P-450 (Cyt P-450) in kidney tissues; levels of retinol-binding protein (RBP), β2-microglobulin (β2-MG) and activity of N-acetyl-β-D-glucosaminidase (NAG) in urine. By contrast a marked drop in activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glucose-6-phosphate dehydrogenase (G6PD), adenosine triphosphatase (ATPase) and the levels of reduced glutathione (GSH), total sulfhydryl group (TSH) were evident in the kidney tissues of LCT exposed group compared to that of control. Furthermore, a sharp drop in the level of uric acid (UA) was also recorded in urine after LCT exposure. Co-treatment of NGN to the LCT-treated rats restored most of the aforementioned indices to near-normal levels. In conclusion, NGN appeared to be a promising agent for protection against LCT-induced nephrotoxicity.

1_The_influence_of_naringenin_on_lambda-cyhalothrin_induced_nephrotoxicity_in_male_rats
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