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Vol.2 No.1 -7 : Potential hepatoprotection exerted by ginseng against chlorpyrifos-induced hepatotoxicity in albino rats.

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By : Bayomy M.F.F., Abdel Samie H. A., Gendia S.E. M.

Abstract

Insecticides gained public reputation and widespread application to control the spread of different insects in various habitats. However, the deleterious effects of these chemicals could not be ignored and should be dealt seriously. The present work was conducted to test the efficacy of the natural plant ginseng in alleviating toxicity of chlorpyrifos. The organophosphorus insecticide chlorpyrifos induced hepatotoxicity and changes in some serum biochemical parameters. The liver of rats administered chlorpyrifos manifested cytoplasmic vacuolization, leucocytic infiltration, hemorrhage and remarkable dilatation of veins. The nuclear chromatin was condensed. There was a significant increase in alanin aminotransferase (ALT) while there was a significant decrease in albumin, catalase (CAT) and superoxide dismutase (SOD) in the serum of treated rats. Treating animals with ginseng was found in this study to alleviate hepatotoxicity and restore the levels of the tested serum parameters to nearly normal values.

7. Potential hepatoprotection exerted by ginseng against chlorpyrifos-induced hepatotoxicity in albino rats.

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Vol.1 No.5 -2 : Efficacy of a novel water soluble curcumin derivative versus Tadalafile in mediating erectile function.

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By : Zaahkouk,SA.M.1, Atta H.M2., Fouad Hanan. 2, Hesham G.A1. Yehia M. Hussein.1

Abstract

The present study was conducted to assess the efficacy of a novel curcumin derivative (NCD) versus Tadalafile in erectile signaling. The study was conducted on 15 control male rats and 75 diabetic male rats divided into the following groups:, diabetic, curcumin, NCD, Tadalafile and NCD combined with Tadalafile . Cavernous tissue gene expression levels of heme oxygenase-1 (HO-1), Nrf2, NFК-β, and p38, enzyme activities of heme oxygenase (HO) and nitric oxide synthase (NOS), cGMP and intracavernosal pressure (ICP) were assessed. Results showed that 12 weeks after induction of diabetes, erectile dysfunction (ED) was confirmed by the significant decrease in ICP, a significant decrease in cGMP, NOS, HO enzyme activities, a significant decrease in HO-1 gene and a significant elevation of NFК-β, p38 genes. Administration of all therapeutic interventions led to a significant elevation in ICP, cGMP levels, a significant increase in HO-1 and NOS enzymes, a significant increase in HO-1, and Nrf2 gene expression, and a significant decrease in NFК-β, p38 gene expression. NCD or its combination with Tadalafile showed significant superiority and more prolonged duration of action. In conclusion, NCD could enhance erectile function with more efficacy and more prolonged duration of action.

2. Efficacy of a novel water soluble curcumin derivative versus Tadalafile in mediating erectile function.

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Vol.1 No.5 -5 : Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

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By : Ezar Hafez; Ahmed Masoud; Magdy Barnous; Ehab Tousson

Abstract

Apoptosis plays a critical role in the development and homeostasis of multicellular organisms, especially those with high cell turnover such as the lymphoid system. The current study aimed to examined the effects of changes in thyroid hormones on apoptosis of spleen in male rats. 30 rats were equally divided into three groups (10 animals each). G1, control group in which animals did not received any treatment; G2, Hypothyroid group in which rats received 0.05% 6-n-propyl-2-thiouracil (PTU) in drinking water for 6 weeks; G3, Hyperthyroid group in which rats received 100 μg/Kg L-Thyroxin sodium administration in drinking water for 6 weeks. In the present study; serum T3 and T4 concentrations were depressed and serum TSH concentration was significantly elevated in rats receiving PTU-induced hypothyroidism. On the other hand; serum T3 and T4 concentrations were significantly elevated and serum TSH concentration was depressed in rats receiving L-Thyroxin sodium-induced hyperthyroidism. In the current study; spleen in both hypothyroid and hyperthyroid rats revealed many of abnormalities as marked disruption of spleen structure, loss in distinction between the white and red pulps, degeneration and vacuolation with an increased in the lymphocyte population. Also, a significant increase in p53 and Caspase3 apoptotic cells and a significant decrease in Bcl-2 antiapoptotic cells in the spleen tissues revealed the possibility of the apoptosis occurrence after PTU or Thyroxin administration in the case of hypothyroidism and hyperthyroidism.

5. Apoptotic Marker Alternations in the Spleen of Experimentally Hyperthyroid and Hypothyroid Rat.

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Vol.1 No.2 -1 : Clomiphene citrate induced kidney injury in female albino rat.

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By : Hawazen A. Lamfon1 and Nahid A. Lamfon2

Abstract

Clomiphene citrate (clomid), a selective oestrogen-receptor modulator, is used in the treatment of polycystic ovary syndrome. On the other hand, it showed many adverse effects. The present work investigates the effects of clomiphene citrate (CC) on kidney of female albino rats. Many biochemical and histological changes were induced in these animals when treated with CC at doses of 50 and 100 mg/kg body weight. Treating animals with doses of 50 and 100 mg/kg body weight caused elevations in serum creatinine and urea. The histological changes in the kidney of treated animals included intertubular leucocytic infiltrations, congestion of blood vessels and degeneration of renal tubules. Moreover, atrophy of glomeruli was recorded. In conclusion, biochemical and histopathological alterations indicated that clomiphene citrate causes renal damage in female albino rats.

1. Clomiphene citrate induced kidney injury in female albino rat.

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