Posts

Vol.7 No.3 – 4:Association between thrombocytopenia and mild infection of COVID-19 patients

/0 Comments/in , , /by

By: Ahmed Abdelhalim Yameny

Society of Pathological Biochemistry and Hematology, Egypt

Abstract

Background: Thrombocytopenia is a common manifestation and also an indicator of poor prognosis of SARS, MERS, and COVID-19 according to previous researches, Some studies have found a relationship between thrombocytopenia and the severity of the COVID-19 and related mortality. Patients and methods: This study included 504 out hospitalized patients with confirmed COVID-19 infection in Alexandria, Egypt, these study subjects were randomly selected irrespective of the age group and both genders were included, EDTA blood sample was collected for performing complete blood count and platelet count (Diagon D-cell 60 hematology analyzer Europe-Diagon Ltd. Hungary). Results: The present study included patients aged from14 years to 75 years mean age was 44.5 ±30.5 who were confirmed to have Covid-19 based on real-time reverse transcription-polymerase chain reaction, the female gender was more frequent (n=280, 55.6%) than Male gender (n=224, 44.4%). This study reveals a normal platelet count in 456 patients (90.5%), and a mild low platelet count of 140-150× 109/L in 48 patients(9.5%), with a p-value, is 0.415 which is more than 0.05 not significant. And no patients in this studied group recorded platelet count less than 140× 109/L. Conclusion: Platelet was not a significant biomarker for COVID-19 diagnosis or prognosis in out-hospitalized patients (Outpatients and patients under home observation).

Association-between-thrombocytopenia-and-mild-infection-of-COVID-19-patients-converted

Download PDF

Vol.7 No.1 – 4: Lactate dehydrogenase level as a COVID-19 biomarker

/0 Comments/in , , /by

By: Ahmed Abdelhalim Yameny

Society of Pathological Biochemistry and Hematology, Egypt

Email: dr.ahmedyameny@yahoo.com

DOI: 10.21608/jbaar.2021.173662

Abstract:

Background: Lactate dehydrogenase (LDH) is an intracellular enzyme found in cells in almost all organ systems, which catalyzes the interconversion of pyruvate and lactate, LDH has been proved to be a prognostic factor with

high accuracy in diseases involving multiple organ injuries such as acute heart failure (AHF) and severe acute pancreatitis (AP), LDH is a potential prognostic biomarker in patients with COVID-19. Patients and methods: This study included 217 non hospitalized patients with confirmed COVID-19 infection in Alexandria, Egypt, these study subjects were randomly selected irrespective of the age group and both genders were included, Assay procedure as manufactory instructions and Reagents of Chema Diagnostics Italy, LDH FL of reagent based on  DGKC recommendations. Results: The percentage of COVID-19 non hospitalized Patients relation to the serum LDH level, The present study included patients aged from14 years to 75 years mean age was 44.5 ±30.5 who were confirmed to have Covid-19 based on real-time reverse transcription-polymerase chain reaction, female gender was more frequent (n=119, 54.8%) than Male gender (n=98, 45.2%). This study reveals high serum LDH levels in 147 patients (67.7%), which was a significant biomarker for COVID-19 diagnosis in non-hospitalized patients (Outpatients and patients under home observation), with a p-value is 0.024 which less than 0.05. Conclusion and Recommendations: Serum LDH level is a good biomarker of infection in COVID-19 Outpatients and patients under home observation increased by 67.7%, many other studies revealed LDH is a good marker for COVD-19 hospitalized patients and severe infection.

Lactate dehydrogenase level as a COVID-19 biomarker-converted (3

Download PDF