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Vol.6 No.4 – 1: Evaluation of the cardioprotective effect of l-carnitine and silymarin in cancer patients receiving anthracycline-containing chemotherapy

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By: Zeinab Al kasaby  Zalat* 1, Hosny A. Elewa2,Mohamed Abdel-Latif3 , Mohamed A. Alm El-Din4, Neeven A. Kohaf 5

  1. Assoc. Professor and Head of Clinical Pharmacy Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. (Pharm.D., Ph.D.) (zeinabalkasaby.pharmg@azhar.edu.eg)
  2. Assoc. professor and Head of Pharmacy Practice Department, Faculty of Pharmacy, Horus University, Dominate City, Egypt. (Pharm.D, Ph.D.)
  3. Professor and Head of Clinical Pharmacy Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt. (Ph.D.)
  4. Assoc. Professor, Department of Clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt. (MD)
  5. Master degree in pharmaceutical sciences, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt. (M.Sc.)

Abstract

Aim: Anthracycline-induced cardiotoxicity is the most common constraint of its use in the treatment of various types of cancer. This study aimed to investigate the benefits of the addition of the l-carnitine / silymarin to anthracycline chemotherapy in patients with breast cancer. Methods: 83 patients were recruited from Clinical Oncology Department, Tanta University, Egypt, then prospectively randomized to receive their anthracycline-containing therapeutic regimen, control group (n=33), or anthracycline plus l-carnitine, l-carnitine group (n=25), or anthracycline plus silymarin, silymarin group (n= 25). Blood samples were collected at the beginning and after 6 months to measure LDH, CK-MB, cTn I, Anticardiolipin IgG, Fe, ferritin, and TIBC and % of saturation. % EF was documented. Data were statistically analyzed by ANOVA and paired t-test. P <0.05 was statistically significant. Results: The addition of l-carnitine to anthracycline chemotherapy has a significantly improved EF% (P=0.003), Anticardiolipin IgG (P=0.001), ferritin (P=0.001), and TIBC (P=0.011). The supplementation with silymarin to anthracycline chemotherapy had a statistically significant decrease in Anticardiolipin IgG (P=0.000), iron (P=0.001), ferritin (P= 0.001), TIBC (P=0.007), and % saturation (P=0.001). Silymarin group showed a significant decrease in iron profile compared to the l-carnitine group. Conclusion: The co-administration of l-carnitine or silymarin with anthracycline chemotherapy represents a new therapeutic strategy for better control of anthracycline-induced cardiotoxicity. Silymarin resulted in more beneficial effects on the iron profile compared to l-carnitine with anthracycline or anthracycline chemotherapy alone.

Evaluation-of-the-cardioprotective-effect-of-l-carnitine-and-silymarin-in-cancer-patients-receiving-anthracycline-containing-chemotherapy-converted

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Vol.2 No.12 -2 : Effects of L-carnitine and Ginkgo biloba on Pentylentetrazol-induced liver damage and oxidative stress in rats.

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By : Reda M. Fekry1 , Akaber TH Keshta1 , Wafaa K.Abo-Ghaneima and Ehab Tousson

Abstract

Pentylentetrazol (PTZ) kindling is an acknowledged models for epilepsy. The current study aimed to determine the possible protective and ameliorative effects of Lcarnitine and Ginkgo biloba (GB) against PTZ induced liver injury and oxidative stress in male rats. A total of 80 male albino rats were equally divided into eight groups; 1st group was the control; 2nd and 3rd were GB and Lcarnitine groups, respectively; 4th group was pentylenetetrazole rat group and the 5th and 6th groups were pre and post treated PTZ with L-carnitine groups respectively; the 7th and 8th groups were pre and post treated PTZ with GB respectively. Serum ALT, AST, ALP and MDA in liver tissue were significant increase in PTZ group when compare with control, while serum ALB and CAT, SOD, GST and TAC in liver tissue were significant decrease in PTZ group when compare with control. On other hand post and pre-treatment with L-carnitine and GB improved these parameters. Our results revealed that the treatment with L-carnitine improved these parameters more than GB and the results of post treatment were better than pre-treatment.

2_Effects_of_L-carnitine_and_Ginkgo_biloba_on_Pentylentetrazol-induced_liver_damage_and_oxidative_stress_in_rats
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Vol.1 No.6 -4 : Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat

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By : EhabTousson1;Mohamed F.F Bayomy2and BasiounyFouad El-sendiony٭2

Abstract

Pentylenetetrazole (PTZ) kindling is an acknowledged model for epilepsy and refers to a phenomenon in which repeated injection of this drug causes gradual seizure. The current study aimed to determine the possible protective and ameliorative effects of L-carnitine and Ginkgo bilobaleaf extracts (GLE) against PTZinduced epileptic seizures disease in rats. A total of 80 male albino rats were equally divided into eight groups; 1st group was the control; 2nd and 3rd wereGLE and L-carnitine groups, respectivel; while the 4th group was pentylenetetrazolerat groupand the 5th and 6th groups were pre GLE and L-carnitine groups respectively; the 7th and 8th groups were post GLE and Lcarnitine, respectively. PTZ leads to an increase in malondialdehyde (MDA), glutamate (Glu) and to a decrease in catalase, super oxide dismutase (SOD), glutathione peroxidase (GPx) activity, glutathione reductase(GSH), gamma amino butyric acid (GABA) and acetylcholine esterase (AChE) in the cerebral cortex of rats when compared to control group. Pre- and post treatment with GLE and L-carnitine were improved the biochemicalalterations in cerebral cortex that treated with PTZ.

4. . Effects of L-carnitine and Ginkgo bilobaon cerebral cortex in experimentally-induced epileptic seizures disease in rat.
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