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Vol.4 No.3 – 3 : Nephrotoxicity associated with Orlistat in normal and obese female rats

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By : Ehab Tousson, Ahmed Massoud, Attyat Salem, Shahenda A. Fatoh

Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt.

 

Abstract

Obesity is a global health concern associated with high morbidity and mortality. Therapeutic strategies include synthetic drugs and surgery, which may entail high costs and serious complications. Orlistat is a pancreatic lipase inhibitor licensed for the treatment of obesity. The current study was carried out to elucidate the modulating effect of Orlistat against obesity induced kidney toxicity in female rats. A total of 50 female rats were divided into five groups (G1, Control; G2, Orlistat; G3, Obesity; G4, Co- treated Orlistat with Obesity; G5, Post- treated Obesity with Orlistat rat group). The current study revealed that a significant increase in serum urea, creatinine, while  a significant decrease in the levels of sodium, potassium, calcium and chloride ions levels in treated rats with Orlistat while a significant increase in serum urea, creatinine, sodium, potassium and chloride ions levels in obesity group when compared with control group. In contrast; a significant decrease in serum urea, Creatinine, sodium, potassium and chloride ions levels in treated obese rats with Orlistat when compared with obesity group.  So; Orlistat induced renal toxicity when used for treatment of obesity and self-recovered obese rats is safe and better than the use of Orlistat in treatment of obesity.

Nephrotoxicity associated with Orlistat in normal and obese female rats

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Vol3 No.2 -1 :Prevention of Etoposide induced kidney toxicity, electrolytes, injury and KI67 alternations in male rats treated with star anise

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By :Ali Salman Hassan Al-Ameri

Abstract

Star anise (Illicium verum) has been used in folk medicine of China, India, and most other Asian countries to treat stomach aches, vomiting, insomnia, dermal inflammation and rheumatic pain as well as a common spice usage. The present study was designed to investigate the possible ameliorating effect of star anise fruit extract against Etoposideinduced nephrotoxicity in rats to prove the evidence of its traditional pharmacological effectiveness. A total of 40 male Wister albino rats were divided randomly into four groups (1st group was control; 2nd group was treated with star anise, 3rd group was received Etoposide, and 4th group was treated with both star anise and Etoposide. The administration of Etoposide significantly caused elevation in creatinine, blood urea, sodium, potassium and chloride while calcium ions was significantly decrease when compared with control group. Co-treated rat with star anise and Etoposide maintained the levels of the measured some parameters (creatinine, chloride and calcium ions) closer to the normal values while urea, sodium and potassium ions were significantly decrease when compared with Etoposide group. Histopathological evidence, together with observed Ki67-ir, supported the detrimental effect of Etoposide and the ameliorating effect of star anise water extract on renal toxicity. Finally, it could be concluded that star anise has a promising role and it worth to be considered as a natural substance for ameliorating the renal toxicity and injury induced by Etoposide chemotherapy.

2017 JBSAR Ali Alameri

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