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Vol.8 No.3 – 2:Evaluation of Adiponectin hormone and some biochemical parameters with unstable angina and acute myocardial infarction patients

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By: Alyaa Majid1*, Sevki Adem2, Anwer Sabah Kadhim3

1 Department of Chemistry, College of Science, University of Thi-Qar, Iraq

2  Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey

3 Iraqi Ministry of Health, Iraq

Abstract

The acute coronary syndromes [unstable angina (UA) and acute myocardial infarction (AMI)] are more dangerous than other ischemic heart diseases (IHD) due to acute morphological changes in atherosclerotic plaques which cause (acute ischemia) severe imbalance between myocardium demand and oxygen supply. In this study we investigated adiponectin hormone, creatine kinase(CK), lactate dehydrogenase(LDH), malondialdehyde(MDA), nitric oxide(NO), superoxide dismutase(SOD), and glutathione(GSH)  in patients with unstable angina and acute myocardial infarction, This study has been carried out on 100  patients with unstable angina and acute myocardial infarction and 50 healthy subjects. the study shows that there is a significant difference in the concentration of serum Adiponectin, CK, LDH, MDA, NO, SOD, and GSH between (controls, AMI and UA ) in the (male and female )  groups (p≤0.05).

Evaluation-of-Adiponectin-hormone-and-some-biochemical-parameters-with-unstable-angina-and-acute-myocardial-infarction-patients

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Vol.7 No.4 – 6:The prognostic value of elevated creatine kinase as an Independent Prognostic Factor for COVID-19 mild infection

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By: Sabah Farouk Alabd and Ahmed Abdelhalim Y. Mahmoud

Molecular Biology Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Egypt

DOI: 10.21608/jbaar.2021.237395

Abstract

Background: Creatine kinase (CK), which is a marker of muscle damage, was also often found to be elevated in deceased COVID-19 patients and those with severe disease, Therefore, higher CK could be used as a prognostic marker to indicate a more severe clinical picture of COVID-19. Patients and methods: This study included 225 out-hospitalized patients with confirmed COVID-19 infection, these study subjects were randomly selected irrespective of the age group and both genders were included, Assay procedure as manufactory instructions and Reagents of Spectrum diagnostics, optimized DGKC/IFCC liquid reagent, Egypt are used. Results: This study showed male gender was more frequent (n=135, 60%) than the female gender (n=90, 40%). This study reveals high serum CK levels in 45 patients (20%), which has a sensitivity of 20% as a biomarker for COVID-19 diagnosis in out-hospitalized patients (Outpatients and patients under home observation), with a p-value is <0.001 which is less than 0.05. Conclusion: CKhas a sensitivity of 20% in out-hospitalized patients (Outpatients and patients under home observation), thus elevated CK is best used as a rule-in test rather than a rule-out test.

The prognostic value of elevated creatine kinase as an Independent Prognostic Factor for COVID-19 mild infection 2

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