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Vol.2 No.3 -4 : Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

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By : Osama M. Badr1, Saber A. Sakr2, Hala M. Abd-Eltawab1

Abstract

This study was prepared to explore the effect of ginger extract in defeating the Ehrlich Ascites Carcinoma (EAC) injected subcutaneously in mice and induced solid tumour. After the solid tumour formation; the mice were classified into four groups (control, tumour untreated, ginger and ginger & tumour). Eight mice were grouped separately in each cage. Mice were killed and dissected at the end of this investigation; liver and kidney were removed for histopathological study. The biochemical parameters (ALT, AST, Urea, Creatinine, MDA, SOD and CAT) were measured in the sera of all tested groups. Ginger extract ameliorated the histological structures of both liver and kidney to be near to control, modulated the elevated values of (ALT, AST, Urea, Creatinine and MDA) and reduced values of (SOD and CAT) to record slightly normal readings. Tumour volumes reduced significantly and the destructed genomic DNA retained the normal pattern. Ginger has no pathological effects on control mice.

4. Ameliorative effect of ginger extract against pathological alterations induced in mice bearing solid tumors.

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Vol.1 No.2 -1 : Clomiphene citrate induced kidney injury in female albino rat.

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By : Hawazen A. Lamfon1 and Nahid A. Lamfon2

Abstract

Clomiphene citrate (clomid), a selective oestrogen-receptor modulator, is used in the treatment of polycystic ovary syndrome. On the other hand, it showed many adverse effects. The present work investigates the effects of clomiphene citrate (CC) on kidney of female albino rats. Many biochemical and histological changes were induced in these animals when treated with CC at doses of 50 and 100 mg/kg body weight. Treating animals with doses of 50 and 100 mg/kg body weight caused elevations in serum creatinine and urea. The histological changes in the kidney of treated animals included intertubular leucocytic infiltrations, congestion of blood vessels and degeneration of renal tubules. Moreover, atrophy of glomeruli was recorded. In conclusion, biochemical and histopathological alterations indicated that clomiphene citrate causes renal damage in female albino rats.

1. Clomiphene citrate induced kidney injury in female albino rat.

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Vol.1 No.1 -2 : Ameliorative effect of aqueous extract of rosemary on cadmium – induced kidney injury in albino rats

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By : El-Morsy*, A.M., Sakr, S.A., and Bayomy, M.F

Abstract

Cadmium (Cd) is one of the heavy metals causing risks for living organisms and induced high toxicity to different biological system. Rosemary (Rosemarinus officinalis) is plant widely used in food. It has antimicrobial, antioxidant, anti-carcinogenic properties. The present work studied the effect of rosemary leaf extract on Cd induced kidney injury in rats.Cadmium chloride (30 mg/kg b.w, 5 consecutive days/week for 8 weeks) administration increased renal MDA but decreased GSH, CAT and SOD activities versus control. In parallel, serum urea and creatinine increased. Cadmium chloride caused histological alternations involved shrinkage in glomeruli, congestion in blood vessels, dilation in renal tubules and leucocytic infiltrations. Ultrastructural observations showed abnormality in nucleus, endoplasmic reticulum, brush border, proximal and distal convoluted tubules. In the contrary, administration of aqueous extract of rosemary restored these changes. The results suggested that rosemary ameliorative these changes due to its antioxidant properties by scavenging free radicals resulting from cadmium chloride.