Vol.5 No.4 – 3: Production of Heliomycin from Actinomycete and Evaluation of its Antimicrobial Activities

By: Abdulla A. Mahmoud,Ehab A. Essawy, Mohga S. Abdalla, and Mohamed S. Abdelfattah

¹Chemistry Department, Faculty of Science, Helwan University, Cairo , Egypt

Abstract

Heliomycin (1) was isolated from the culture broth of actinomycete AB5. The structure of the isolated compound (1) was characterized by spectroscopic methods including NMR and mass spectrometry data.The influence of cultural parameters affecting the production of biomass including different culture media, pH values, temperatures and incubation periods were investigated. Maximum production of secondary metabolites (2.78 g/l) was found in the culture medium of Waksman at initial pH 7.5 for four days at 35ºC. The antimicrobial activity of heliomycin (1) was evaluated against Gram-positive bacteria, Gram-negative bacteria and fungi.

Production of Heliomycin from Aquatic Actinomycete and Evaluation of its Antimicrobial Activities

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