By: Asmaa Fathi Galal^1*, Mai Sabry Saleh², Nagat Mohamed Amer², Amal Saad-Hussein²

¹Narcotics, Ergogenics and Poisons department, Medical Research Division, National Research Centre, Dokki, Giza, Egypt

²Environmental and Occupational Medicine Department, Environmental Research Division, National Research Centre, Dokki, Giza, Egypt

Abstract

Objective: The causal effect relation between smoking and stress is a subject that invites continuous research.  Hypothetically, investigation of stress biomarkers that are reported to be affected by tobacco intake may give us some explanation of the association between stress and smoking as a habit.  Consequently, the aim of the present study was to assess serum level of some stress biomarkers and compare them among smokers and non-smokers in a sample of Egyptian male health volunteers. Methods: Fifty-nine subjects were enrolled in the study (29 smokers and 30 non-smokers of matched age and gender). We measured serum levels of cortisol and interleukin-6 (IL-6) using ELISA technique, and serum levels of α-amylase, triglycerides (TG), and total cholesterol (TC) using colorimetric methods. Results: Serum cortisol levels were decreased in smokers, and IL-6, TG and TC were significantly higher in smokers than non-smokers, whereas, serum α-amylase did not show significant difference. Serum cortisol showed to be negatively correlated with serum IL-6 in smokers. Conclusions: The present studyassumes that smokers suffer from a state of chronic stress as evidenced by the observed decrease in serum cortisol due to negative feedback effect and increase in levels of serum IL-6, TG and TC. This in turn enhances craving to smoke to face stressors and leads to a vicious circuit that smokers fail to quit smoking.

Comparing the level of some stress biomarkers among smoking and non-smoking health adults in Egypt-PDF

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