By : Abdel Razik H. Farrag1, Rania A. Ibrahim2, Shimaa N. El-Sayed2

Abstract

Gentamicin is an antibiotic whose clinical use is limited by its nephrotoxicity. Coenzyme Q10 (CoQ10) is an effective antioxidant and used for therapy of a number of diseases. The present study was designed to investigate the possible protective effect of CoQ10 against gentamicin induced nephrotoxicity in mice. Thirty five adult male mice were used in this study and were randomly divided into five groups, each consisting of seven animals as follows: group I: normal control; group II: treated with CoQ10 (30 mg/kg/day, orally for 14 days); group III: treated with gentamicin (80 mg/kg/day, i.p. for 14 days); group IV: treated with CoQ10 and gentamicin for 14 days; group V: treated with gentamicin (80 mg/kg/day) i.p. for 14 days, after that the animals were given CoQ10 (30 mg/kg/day) orally for 7 days. At the end of the experiment, blood was collected and serum was separated for the estimation of serum creatinine and urea. Then the mice were sacrificed and kidneys were removed for histopathological study. The biochemical results showed that Coenzyme Q10 administration with gentamicin injections significantly decreased serum urea and creatinine when compared with gentamicin group. Light microscopic examination of the renal tissues from gentamicin-treated mice revealed severe histopathological changes, whereas specimens obtained from CoQ10 treated mice revealed only mild changes. Conclusion: It appears that CoQ10 has some protective role against gentamicin induced nephrotoxicity.

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7. Protective effect of Coenzyme Q10 against gentamicin induced acute renal failure in mice.
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