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Vol.9 No.2-3:COVID-19 Laboratory diagnosis methods

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By: Ahmed Abdelhalim Yameny

Society of Pathological Biochemistry and Hematology, Egypt

Abstract

Coronavirus-19 is caused by “Severe acute respiratory syndrome coronavirus-2” (SARS-CoV-2), COVID-19 pandemic, has led to millions of confirmed cases and deaths worldwide. Efficient diagnostic tools are in high demand, as rapid and specific testing plays an important role in patient management and decelerating disease spread. the current technologies used to detect COVID-19 in clinical laboratories will be classified into main three categories, I– The polymerase chain reaction (PCR) method, II– Immunological or serological methods (Antigen and Antibody Detection), III– Biochemical and hematological methods which include 1- Inflammatory biomarkers (Elevated and decreased group), 2.Multi-organ damage/failure (Cardiac, Hepatic, and Renal).

COVID-19-Lab-Diagnosis-methods

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Vol.8 No.3 – 3: Biochemical changes in Egyptian patients infected with COVID-19

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By: Ahmed M. El-Adly1*, Ahmed A. Wardany1, Mohey H. Shikhoun2

1Botany and Microbiology Department, Faculty of Science, Al-Azhar University, 71524Assiut Branch, Egypt ahmedeladly.ast@azhar.edu.eg, ahmed_wr2000@azhar.edu.eg

2Analysis and Laboratories Department, Higher Technological Institute of Applied Health Sciences in Sohag, Ministry of Higher Education, Cairo, Egypt.; moheyshikhoun@gmail.com

Abstract

A pandemic-scale outbreak of the newly discovered coronavirus disease 2019 (COVID-19), fast-spreading viral pneumonia, is currently occurring. Due to the disease’s overall vulnerability, different age groups have different clinical characteristics and test findings. The purpose of this study was to describe the COVID-19 laboratory results in various age and sex groups. Reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-2 RNA was used in the study, which had 1100 individuals with typical cold symptoms. It was reported that 660 of these cases tested positive for the test, while 440 tested negatives, therefore all cases underwent laboratory testing. Our research revealed that males had higher COVID-19 positivity than females (215/660; 67.4%), with males scoring 445/660; 32.6%). Age does not statistically differ between COVID-19 positive and negative cases. Hematological parameters in blood cells revealed that Lymphocytes differ significantly between COVID-19-infected and uninfected patients as these cells decline in the presence of COVID-19 infection. There are no significant differences in hemoglobin (Hgb percent), red blood cells (RBCs), total white blood cells (WBCS), basophils, neutrophils, monocytes, and eosinophils, as well as blood platelets (PLTS). Erythrocyte sedimentation rate (ESR) is unimportant, whereas COVID-19 infection increases ferritin and C-reactive proteins.

Biochemical-changes-in-Egyptian-patients-infected-with-COVID-19-1

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Vol.6 No.3 – 5: Standpoints on immune responses against COVID-19

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By: Mabrouk A. Abo-Zaid1, Ahmed H. Ismail1, Ali H Amin2, 3

1: Biology department, faculty of science, Jazan University, Jazan, Saudi Arabia

2: Deanship of Scientific Research, Umm Al-Qura University, Makkah, Saudi Arabia;

3: Zoology Department, faculty of science, Mansoura University, Mansoura, Egypt;

Abstract

COVID-19 pandemic disease has firstly occurred in Wuhan, Hubei, China. Then the infection spread globally. Many researchers now suggest the strong similarities of COVID-19 with the previous pathogenic human beta coronaviruses SARS-CoV and MERS-CoV. But there is limited knowledge about the immune response to COVID-19. So on the basis of the immune response of these viruses, we will try to predict how the immune system can deal with this infection. In this review, we focus on human coronavirus types and discuss current knowledge of immune response against SARS-CoV and MERS-CoV immune response, which may be helpful in offering the perspectives on immune responses against COVID-19.

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