By : Mohamed M. Omran^a*, Faten M. Zahran^b, Mohamed Kadry^c,

Arafa A. M. Belal ^c, Reihan M.S^d

^a Chemistry Department, Faculty of Science,  Helwan University, Cairo, Egypt;

^b Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt;

^c Chemistry Department, Faculty of Science, Port Said University, Port Said, Egypt;

 ^d Cardiology Department, Faculty of  Medicine, New Damietta, Al-Azhar University, Egypt;

*Corresponding author: Mohamed Mostafa Omran, PhD: E-mail: drmmomran@yahoo.com

Abstract

Background:Acute myocardial infarction (AMI) controlled and promoted by inflammation within coronary plaque. Monocyte chemoattractant protein-1 (MCP-1) is pro-inflammatory mediator, that’s playing a major role in plaque rupture. This study aimed to assess the diagnostic performance of MCP-1 for early diagnosis of AMI among chest pain (CP) patients. Methods: MCP-1 and cardiac Troponin I (cTnI) were performed for all studied patients. Receiver operating characteristic (ROC) curve was used to assess the diagnostic accuracy of biomarkers. Results: Baseline level of MCP-1 has good capacity for discriminating patients with AMI from non coronary chest pain (NCCP), stable angina (SA) and unstable angina (UA)  patients with efficiency 91%, 91% and 83%; Respectively. Area under the curves (AUCs) of MCP-1 for diagnosis AMI patients at 0-6 hours and > 6-12 hours after onset time of CP were 0.69 (P < 0.001); and 0.71(P < 0.0001); respectively, compared with cTnI were 0.58 (P < 0.001) and 0.67 (P < 0.001); respectively. However, at > 12-24 hours, cTnI has AUC 0.93 (P < 0.0001) compared with MCP-1 0.74 (P < 0.0001). In conclusion: Independent early baseline MCP-1 has given sufficient diagnostic information for patients with AMI.

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Role of Monocyte Chemoattractant Protein-1 for Diagnosing

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