Vol.8 No.3 – 3: Biochemical changes in Egyptian patients infected with COVID-19

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By: Ahmed M. El-Adly1*, Ahmed A. Wardany1, Mohey H. Shikhoun2

1Botany and Microbiology Department, Faculty of Science, Al-Azhar University, 71524Assiut Branch, Egypt ahmedeladly.ast@azhar.edu.eg, ahmed_wr2000@azhar.edu.eg

2Analysis and Laboratories Department, Higher Technological Institute of Applied Health Sciences in Sohag, Ministry of Higher Education, Cairo, Egypt.; moheyshikhoun@gmail.com

Abstract

A pandemic-scale outbreak of the newly discovered coronavirus disease 2019 (COVID-19), fast-spreading viral pneumonia, is currently occurring. Due to the disease’s overall vulnerability, different age groups have different clinical characteristics and test findings. The purpose of this study was to describe the COVID-19 laboratory results in various age and sex groups. Reverse transcriptase polymerase chain reaction (RT-PCR) for SARS-2 RNA was used in the study, which had 1100 individuals with typical cold symptoms. It was reported that 660 of these cases tested positive for the test, while 440 tested negatives, therefore all cases underwent laboratory testing. Our research revealed that males had higher COVID-19 positivity than females (215/660; 67.4%), with males scoring 445/660; 32.6%). Age does not statistically differ between COVID-19 positive and negative cases. Hematological parameters in blood cells revealed that Lymphocytes differ significantly between COVID-19-infected and uninfected patients as these cells decline in the presence of COVID-19 infection. There are no significant differences in hemoglobin (Hgb percent), red blood cells (RBCs), total white blood cells (WBCS), basophils, neutrophils, monocytes, and eosinophils, as well as blood platelets (PLTS). Erythrocyte sedimentation rate (ESR) is unimportant, whereas COVID-19 infection increases ferritin and C-reactive proteins.

Biochemical-changes-in-Egyptian-patients-infected-with-COVID-19-1

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Vol.8 No.3 – 2:Evaluation of Adiponectin hormone and some biochemical parameters with unstable angina and acute myocardial infarction patients

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By: Alyaa Majid1*, Sevki Adem2, Anwer Sabah Kadhim3

1 Department of Chemistry, College of Science, University of Thi-Qar, Iraq

2  Department of Chemistry, Faculty of Science, Ataturk University, 25240 Erzurum, Turkey

3 Iraqi Ministry of Health, Iraq

Abstract

The acute coronary syndromes [unstable angina (UA) and acute myocardial infarction (AMI)] are more dangerous than other ischemic heart diseases (IHD) due to acute morphological changes in atherosclerotic plaques which cause (acute ischemia) severe imbalance between myocardium demand and oxygen supply. In this study we investigated adiponectin hormone, creatine kinase(CK), lactate dehydrogenase(LDH), malondialdehyde(MDA), nitric oxide(NO), superoxide dismutase(SOD), and glutathione(GSH)  in patients with unstable angina and acute myocardial infarction, This study has been carried out on 100  patients with unstable angina and acute myocardial infarction and 50 healthy subjects. the study shows that there is a significant difference in the concentration of serum Adiponectin, CK, LDH, MDA, NO, SOD, and GSH between (controls, AMI and UA ) in the (male and female )  groups (p≤0.05).

Evaluation-of-Adiponectin-hormone-and-some-biochemical-parameters-with-unstable-angina-and-acute-myocardial-infarction-patients

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Vol.8 No.3 – 1:Evaluation of Serum Ferritin in Type-2 Diabetes Mellitus Sudanese Patients

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By: Hayat Elmaleeh Almobarak Ahmed and Nour Mahmoud Abdelateif Ali

Department of Hematology, Faculty of Medical Laboratory Sciences, Alneelain University, Khartoum, Sudan

Abstract

Background: Type 2 diabetes mellitus (DM2) is an important health problem worldwide affecting about 8 percent of the population. Diabetes Mellitus is one of the most common chronic diseases in Sudan. These patients have many changes in their blood, and many factors affect the glucose tolerance that is mediated by insulin, one of these changes is S.ferritin level, a marker of iron storage. Increased serum ferritin, reflecting body iron overload, is often associated with insulin resistance. The role of iron in the pathogenesis of diabetes is suggested by an increased incidence of type2 diabetes mellitus in diverse causes of iron overload, and reversal or improvement in glycemic control with a reduction in iron load achieved using either phlebotomy or iron-chelating therapy.

Aim: To evaluate serum ferritin level in type-2 Diabetes Mellitus Sudanese Patients.

Materials and Method: A case-control study was done in 45diabetic patients and 45normal healthy individuals as a control group, including measurement of serum ferritin by an electrochemiluminescence immunoassay (ECLIA) method full automated chemical analyzer. COBAS e411 machine used Roche HITACHI Kit and quantification of HbA1c level by i-chroma instrument.

Results: The study showed that serum ferritin levels were significantly increased in diagnosed cases of type 2 diabetes mellitus in comparison with the age and gender-matched healthy individuals (P. value= 0.008). There was an insignificant correlation between serum ferritin and HbA1c(P. value=0.431). 

Conclusion: Therefore, the findings of the present study indicate that serum ferritin was increased in diabetes and this increase may contribute to the pathogenesis of this disease as well as to the development of complications. Thus, routine screening for serum ferritin concentration in pre-diabetes and diabetic patients should be done to assess the body’s iron stores.

Evaluation Of Serum Ferritin In Type2 Diabetes Mellitus Sudanese Patients

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