Vol.4 No.4 – 10 : Breast cancer risk associated with genotype polymorphism of COMT gene in young women

By : Abbas Ch. Mraissl

Pathology /Biology Department ,Education College , Missan University, Iraq

Abstract

O- methelation mediated by COMT enzyme  is an important mechanism for in activating Catechole Estrone (CE) which including 2- HE and 4- HE and transform it to 2-ME and 4-ME which act as anti- tumor genesis . Aim of this study was investigation  the association between the polymorphism in COMT genotype and the breast cancer risk in (40) young  patient’s women aged between (20-39) years were diagnosed and confirmed with breast carcinoma at AL- Sadder hospital in Missan, and (40) healthy control women aged between (18-39) years in period  between     September -2009 to April -2010 Odds ratios(OR) and confidence interval (CI) were calculated in level significant   P < 0.05. The statistical analysis showed no association between the breast cancer risk in young women and homozygous wild (Met/Met) genotype with an OR of 0.63(95%CI= 0.248 – 0.552 ), also with heterozygous  (Val/Met) genotype with an OR of 0.93 (95%CI= 0.155 – 0.44  ), and when a combination (Met/Met + Met/Val) genotype with an OR of 0.78(95%CI= 0.559-0.841), compared to homozygous mutant  (Val/Val) genotype. No significant differences in frequency of low activity alleles between cases and controls, indicating the polymorphism as a single factor may not contribute to breast carcinogenesis in young women.

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